Radiation-Induced Neoplastic Transformation in vitro, Hormesis and Risk Assessment
نویسندگان
چکیده
منابع مشابه
Radiation-induced neoplastic transformation in vitro, hormesis and risk assessment.
Dose-response curves for various low-LET radiation sources have consistently been demonstrated to be J-shaped for the cancer-relevant endpoint of neoplastic transformation in vitro. Most of these studies have been performed where the radiation has been delivered at intermediate to high dose-rates (30-3000 mGy/min), where the threshold dose for induction of neoplastic transformation is around 10...
متن کاملRadiation hormesis and adoptive response induced by low doses of limiting radiation
Ionizing radiation has long been known to produce detrimental biological effects. Although these harmful effects are the results of high doses of exposure, some other maladies such as mutation and cancer seems to be induced at low doses of exposure. In recent decades, however, some pioneer scientists have indicated that ionizing radiation like many other essential agents has toxic effects ...
متن کاملRadiation Hormesis
The word “hormesis” is derived from the Greek word “hormaein” meaning: “to excite,” which is the origin of the word “hormone.” In 1902, the English physiologist, E. Starling, discovered that an acid extract from the human duodenum contained a substance designated as secretin that, when discharged into the bloodstream, stimulated the pancreas to release its secretions when food has passed throug...
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Current guidelines for cancer risk assessment emphasize a toxicant's "mode of action", rather than its empirically derived dose-response relationship, for determining whether linear low-dose extrapolation is appropriate. Thus, for reasons of policy, demonstration of hormesis is generally insufficient to justify a non-linear approach, although it may provide important insights into the actions o...
متن کاملSuppression of neoplastic transformation in vitro by low doses of low LET radiation.
A major concern of exposure to low doses of radiation is the risk of cancer induction. Epidemiologic data are rarely powerful enough to accurately discriminate this risk at doses <10 cGy. In order to gain insight into events at these low doses, laboratory-based studies of relevant endpoints are required. One such endpoint is radiation-induced neoplastic transformation in vitro. Such studies can...
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ژورنال
عنوان ژورنال: Dose-Response
سال: 2007
ISSN: 1559-3258,1559-3258
DOI: 10.2203/dose-response.06-010.redpath